Epidemiology of multiple sclerosis pdf free download. Multiple sclerosis has historically been classified as an organ. Multiple sclerosis epidemiology in middle east and north africa. There is increasing incidence and prevalence of ms in both developed and developing countries 2, the underlying cause of which remains uncertain. Multiple sclerosis ms is the most widespread disabling neurological condition of young adults around the world. We present a systematic epidemiological study with recent prevalence and incidence rates of ms in bavaria. There was no change in ms prevalence in patients below the age of 50, but annual rates of increase. The prevalence and incidence of ms in iran is reported to range from 5. Multiple sclerosis ms is one of the leading causes for disability in young adults with a major impact on quality of life of the affected persons 1, 2. Background multiple sclerosis ms is one of the most common neurological disorders and is one of the main causes of disability. The uneven distribution of multiple sclerosis ms across populations can be attributed to.
Siponimod is a sphingosine1phosphate receptor agonist, and clinical trials in the past decade have shown good prospects for the treatment of multiple sclerosis. Others may experience more energy than normal and have prickling, stinging, or numbness. To validate a case definition of multiple sclerosis ms using health administrative data and to provide the first provincewide estimates of ms incidence and prevalence for saskatchewan, canada. Populationbased data from 1985 to 2011 suggest an increase of prevalence of ms worldwide. Multiple sclerosis ms, an immunemediated demyelinating disease, is the leading cause of neurological disability among young and middleaged adults national multiple sclerosis society, 2014, with a peak onset at about age 33 yr simmons, 2010. Incidence and prevalence of multiple sclerosis in the uk 1990. The availability of treatments for multiple sclerosis ms has increased substantially over the past decade.
Epidemiology of multiple sclerosis jonathan howard, mda, stephen trevick, mdb, david s. Jan 17, 2017 kochhenriksen n, sorensen ps 2010 the changing demographic pattern of multiple sclerosis epidemiology. The estimated prevalence of ms in europe over the past three decades is 83 cases per 100,000, with higher rates in northern countries, and the mean annual incidence is 4. Studying changes in the incidence and prevalence could reveal temporal and spatial patterns contributing to variable ms risk across populations. Latitude is significantly associated with the prevalence of multiple sclerosis. Rising prevalence of multiple sclerosis in saudi arabia, a. Multiple sclerosis mortality rates and 95% confidence intervals cis per 100,000 population were generated using spss version 20. Fromont a, binquet c, sauleau e, fournel i, despalins r, rollot f, et al. The changing demographic pattern of multiple sclerosis epidemiology author links open overlay panel nils kochhenriksen md a b per soelberg sorensen md c show more. Oct 28, 2015 multiple sclerosis is a difficult disease to diagnose because the symptoms can be very different for people. We also did a manual search of reference lists from primary articles and.
Epidemiology of multiple sclerosis in the northeast grampian region of scotlandan update. Age of onset, epidemiology, incidence, multiple sclerosis. Incidence and prevalence of multiple sclerosis in the uk. The epidemiology of multiple sclerosis in scotland. Some people may feel lethargic all day and have burning sensations that are painful. Multiple sclerosis ms is a chronic immunemediated demyelinating disease of the central nervous system cns and represents a major cause of neurological disability in young adulthood 1, 2. The epidemiology of multiple sclerosis in latin america. Setting the study was carried out in the general practice research database gprd, a. Epidemiology is essentially the study of disease in people. Europe pmc is an archive of life sciences journal literature. Objectives to estimate the incidence and prevalence of multiple sclerosis ms by age and describe secular trends and geographic variations within the uk over the 20year period between 1990 and 2010 and hence to provide updated information on the impact of ms throughout the uk.
Review of services available to those with neurological conditions. New insights into geneenvironment and genegene interactions complicate interpretations of demographic epidemiology and have made obsolete the idea of simple causative associations between genes or the environment and ms. Different ms subtypes are being described, and healthcare providers should stay abreast of the different clinical presentations, effective management, and progression of the disease. The epidemiology of multiple sclerosis in latin america and. Epidemiological studies have helped to identify factors that may be related to the risk of developing ms, such as latitude, migration patterns, genetics and infectious processes. The latitudinal correlation vanishes completely for western europe if prevalence is replaced by incidence r 2 0000. Efficacy and safety of siponimod for multiple sclerosis. Therefore, this study was conducted to investigate the prevalence and. Setting the study was carried out in the general practice research database. In relapsing onset multiple sclerosis, gender, age at onset, residual deficit after the first relapse and relapses during the first 2 years of multiple sclerosis were found to be independent. Multiple sclerosis ms is an inflammatory demyelinating disease of unknown origin. Changing population patterns and the effects of comorbidity. The most common age of onset for ms is 2040 years, and the.
Multiple sclerosis epidemiology in europe springerlink. The most striking changes in demographic epidemiology of ms, ascertained over the past decades. Brains observations highlight the changing epidemiology of ms over the last century which are likely to provide the platform in striving towards elucidating ms causation, notably a seemingly reduced latitudinal gradient of ms incidence, an increasing femaletomale sex ratio and an increasing disease rate in darkskinned compared to light. Multiple sclerosis multiple sclerosis affects more than 2 million people worldwide and is currently incurable. A 60year followup of the incidence and prevalence of. Given the onset of ms at such an early age, the effects of this disease may be more detrimental than those of many other neurological conditions. We used populationbased health administrative data between january 1, 1996 and december 31, 2015 to identify individuals with ms using two potential case definitions. Multiple sclerosis ms is a chronic autoimmune disease affecting the myelinated axons of the central nervous system. Vitamin d and multiple sclerosisfrom epidemiology to. Multiple sclerosis is a difficult disease to diagnose because the symptoms can be very different for people. Worldwide, incidence and prevalence of multiple sclerosis ms have increased over the last decades. There are no systematic and metaanalysis studies on ms in iran. The most striking changes in demographic epidemiology of ms, ascertained over the past decades, are 1 an increase in prevalence of ms, predominantly due to longer survival. Multiple sclerosis prevalence in malaga, southern spain estimated by the capturerecapture method.
Hazard ratios for multiple sclerosis according to age at menarche and 3 different definitions of multiple sclerosis outcome among women from the danish national birth cohort 19962002. Multiple sclerosis ms is a complex, chronic inflammatory, progressive neurologic disorder that is the leading cause of non. Incidence and prevalence of multiple sclerosis in europe. Younger, md, mph, msc epidemiology prevalence and incidence the americas in 2007, poser and brinar1 noted that published prevalence rates of multiple sclerosis ms could be misleading with the reliance on clinical information and brain mri inter. Epidemiology while multiple sclerosis is not contagious or directly inherited, epidemiologists scientists who study patterns of disease have identified factors in the distribution of ms around the world that may eventually help determine what causes the disease. A number of interventions to modify the course of multiple sclerosis have been develop. Multiple sclerosisepidemiologyprevalencemiddle eastnorth africa. Longterm followup studies on prevalence and incidence of multiple sclerosis ms for more than five decades are rare and has previously only been conducted in a 95year followup study in olmsted county, minnesota, usa,1 and a 50year followup study from hordaland county, western norway. Epidemiology of multiple sclerosis and vitamin d levels in.
Multiple sclerosis ms is the most common immunemediated inflammatory demyelinating disease of the central nervous system. Diagnosing patients with idiopathic inflammatory demyelinating diseases has been greatly aided by the evolution in diagnostic criterion, the identification of new biomarkers, and improved accessibility to neuroimaging in the country. Nearly 1 million are living with ms in the united states, according to a study funded by the national ms society. The changing demographic pattern of multiple sclerosis epidemiology nils kochhenriksen, per soelberg sorensen the uneven distribution of multiple sclerosis ms across populations can be attributed to di.
The changing demographic pattern of multiple sclerosis epidemiology. This article aimed to report initial findings of the registry and regional prevalence of ms. Multiple sclerosis ms is the most frequently seen demyelinating disease, with a prevalence that varies considerably, from high levels in north america and europe 100100,000 inhabitants to low rates in eastern asia and subsaharan africa 2100,000 population. Approximately 85% of affected people have a relapsingremitting course, characterized by an unpredictable course of exacerbations and remis. Initial evaluations for multiple sclerosis in a university multiple sclerosis center. Multiple sclerosis ms is a relatively uncommon disease, but the effects can be devastating for patients with this disease. Factors that moderate activity limitation and participation.
Original research the prevalence of multiple sclerosis in. Prevalence and incidence surveys could be affected by inaccuracy of diagnosis and ascertainment, and prevalence also depends on survival. But there is a lack of comprehensive understanding of the doseeffect relationship and safety in different subtypes of multiple sclerosis at present. The uneven distribution of multiple sclerosis ms across populations can be attributed to differences in genes and the environment and their interaction. Multiple sclerosis prevalence in malaga, southern spain. Few studies have addressed the possible association between age at menarche and multiple sclerosis ms, and results are conflicting. N, a region with high ultraviolet radiation values during the whole year which is located far apart from iberian. The changing prevalence of multiple sclerosis in northern ireland with reference to benign multiple sclerosis. Despite the availability of advanced diseasemodifying and symptomatic therapies that may decrease activity and progression of disease and alleviate complaints to a certain extent, there is still a need for comprehensive rehabilitation interventions in order to reduce sequels and symptoms of the. But there is a lack of comprehensive understanding of the doseeffect relationship and. Incidence of multiple sclerosis among european economic area populations, 19852009. Multiple sclerosis is the most common demyelinating disease of the central nervous system with serious social and economic burden. It looks at the patterns, causes and effects of health and disease conditions in defined populations.
Multiple sclerosis ms is a chronic and demyelinating disease of the central nervous system cns. Multiple sclerosis ms is an uncommon disease in multiracial malaysia. Frontiers a systematic assessment of prevalence, incidence. Mortality rates100,000 population for ms and all causes were calculated using data derived from statistics canada, agestandardized to the 2006 population. Incidence and prevalence of multiple sclerosis in the uk 19902010.
The latter observation should prompt epidemiological studies to focus on changes in lifestyle in females. Ps the changing demographic pattern of multiple sclerosis epidemiology. Russell w brain and the aetiology of multiple sclerosisa. The epidemiology of multiple sclerosis in three australian cities. You can develop ms at any age, but most people receive diagnoses between the ages. To investigate the spectrum of multiple sclerosis in malaysia. Multiple sclerosis ms progression to mortality may not be solely determined by the underlying autoimmune process. Ms is characterized pathologically by multifocal areas of demyelination with loss of oligodendrocytes and astroglial scarring.
Background low levels of 25hydroxyvitamin d 25ohd have been described as one of the possible environmental factors involved in multiple sclerosis ms etiopathogenesis. This study examined mortality due to multiple sclerosis ms in canada, 19752009 to determine whether there has been a change in age at death relative to the general population and decrease in ms mortality rates. Multiple sclerosis mortality rates in canada, 19752009. The changing demographic pattern of multiple sclerosis. The epidemiology of multiple sclerosis in latin america and the caribbean.
Article information, pdf download for the changing face of multiple. National estimate of multiple sclerosis incidence in france 20012007. Patients who exhibit this pattern are relatively rare. Its aetiology is unknown, but as for many complex diseases, environmental, genetic and immunologic factors have all been implicated 1. The perspective has its origins in demography but finds a compatible conceptual home in public health and epidemiology in particular. Incidence and prevalence of ms stratified by gender, age groups and region were analyzed by data records from 2006 to 2015 of more than 10 million people insured by. Rehabilitation interventions in multiple sclerosis. Europe is a region with high prevalence rates with half of the persons reported to be affected by ms in the world living in europe 3, 4. Establishing the incidence and prevalence of multiple sclerosis in saskatchewan volume 45 issue 3 lina h. We conducted a study in a large cohort of ms patients with the aim of describing characteristics of ms patients and identification of predictors for allcause mortality in this patient group. To establish an updated prevalence and incidence figure for multiple sclerosis on 1 july 1993, to determine the fate of the 374 patients prevalent in 1990, and to establish the origin of incident patients. To assess multiple sclerosis ms incidence from 1998 to 2007, and.
Multiple sclerosis ms is the most common chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. Establishing the incidence and prevalence of multiple. Both genetic and environmental factors seem to interplay a role in its etiopathogenesis handel et al. Multiple sclerosis is a complex, heterogeneous disease associated with longterm disability. Department of epidemiology research, statens serum institut, artillerivej 5, 2300 copenhagen, denmark. We will search pubmed, embase, cochrane library, clinical.
672 1175 729 629 977 1566 288 1428 1611 931 1351 1407 826 921 637 1490 1423 182 761 850 1528 473 37 68 931 1227 1467 206 864 275 51 444 252 840 1468 1377